Many medications are available in several dosage forms, the most common of which are tablets and injectable solutions. As is known, injection forms have some advantages over tableted oral forms, such as: more complete bioavailability, rapidity of action, accuracy of dosing, the possibility of administration to patients who are unconscious, etc. Therefore, in some cases, injections are more preferable. This applies to a drug such as Platifillin hydrotartrate, the injections of which can quickly alleviate the condition of the patient.
Composition and pharmacological action of Platyphylline
Platifillin is an alkaloid obtained from a plant broad-leaved pea. Platifillin hydrotartrate for injections is a colorless transparent liquid containing 0.2% of the active substance, and distilled water is included as an auxiliary component. The drug is packaged into glass ampoules of 1 ml.
The drug, getting into the body, has the following effect:
- direct myotropic antispasmodic effect on the smooth muscles of internal organs and blood vessels;
- vasodilation and some reduction in blood pressure (in high dosages);
- mild sedative effect on the central nervous system;
- suppression of gastric secretion, reduction of contractile activity of the alimentary tract (in high dosages);
- slowing down the secretion of salivary, bronchial and sweat glands, eye accommodation, increased heart rate (in small doses);
- improved conduction of the heart;
- excitation of the brain and spinal cord, respiratory center, etc.
Indications for the use of injections of platyphylline hydrothratha
Injection (subcutaneous, intravenous, intramuscular) administration of the drug is recommended in the following cases:
- spasms of smooth muscle organs (renal, intestinal, biliary colic);
- peptic ulcer;
- an attack of pancreatitis;
- bronchial asthma ;
- laryngospasm;
- arterial hypertension;
- spasms of cerebral vessels and peripheral vessels;
- angina pectoris ;
- bronchorrhea;
- algodismenorea, etc.
Platifillin hydrotartrate in combination with other drugs
In an inpatient setting, acute plaque pain for injections is often treated with platyphylline as part of "lytic mixtures", which usually include substances such as promedol and diphenhydramine. In addition, sometimes Platyphylline is used in combination with Papaverine, but not for injections, but for oral administration.
Side effect of Platyphylline
When treating this drug, the following unpleasant effects may occur:
- dizziness;
- headache;
- dry mouth;
- convulsions;
- difficulty swallowing;
- retention of urine;
- tachycardia;
- dilated pupils, etc.
Contraindications to the use of injections of Platyphylline
Do not use platifillin hydrotartrate injections in the following cases:
- hypersensitivity to the active substance of the drug;
- atrial fibrillation;
- tachycardia;
- cardiac ischemia;
- acute bleeding;
- increased body temperature;
- reflux esophagitis;
- intestinal atony;
- glaucoma;
- liver failure;
- kidney failure;
- chronic lung diseases;
- gestosis, etc.
When treating this drug should refrain from activities that require concentration of attention, rapid reaction. Data on the possible use of the drug during pregnancy and lactation is not available.