Prednisolone in the form of tablets is a fairly common hormonal drug, which is prescribed as part of complex therapy for various diseases. The drug has a fairly powerful systematic effect and has a large number of contraindications, so it is prescribed to patients with caution and after a preliminary examination.
Composition and pharmacological action of tablets Prednisolone
The main active substance in this preparation is prednisolone, a synthetic analogue of the hormones cortisone and hydrocortisone secreted by the adrenal cortex (one tablet contains 5 mg of active substance). Auxiliary components are:
- milk sugar;
- starch;
- calcium stearate.
The drug is rapidly absorbed from the gastrointestinal tract, penetrates into the blood and, through the action of the active substance, produces the following curative effect:
- immunosuppressive (due to inhibition of the release of cytokines from lymphocytes and macrophages);
- Anti-inflammatory (mainly with the participation of cytosolic receptors);
- antiproliferative (due to inhibition of the production of nucleic acids in the cells of the basal layer of the epidermis and fibroblasts of the dermis);
- antiallergic (by reducing the number of basophils and direct inhibition of synthesis and production of biologically active substances);
- suppression of proliferation of pathological connective tissue and growth of tumor cells;
- decreased capillary permeability;
- increased blood glucose levels;
- normalization of respiration with angioneurotic edema ;
- withdrawal of itching and pain.
Therapeutic effect is achieved 1.5 hours after taking the drug and lasts for 18 to 36 hours. It should be taken into account that the toxic effect on the body of unbound prednisolone is possible in the case of a decrease in the amount of protein in the blood plasma. The drug is excreted in the urine and feces, decomposing, mainly in the liver.
Indications for the use of tablets Prednisolone
According to the instructions for the drug Prednisolone Nycomed (the form of the pill - the pill), the main indications for this medicine are:
- acute allergic reactions;
- bronchial asthma;
- asthmatic status;
- thyrotoxic reaction and thyrotoxic crisis (prevention and treatment);
- acute adrenal insufficiency;
- hepatitis acute;
- cirrhosis of the liver;
- poisoning with burning liquids, etc.
Prednisolone is also prescribed to relieve symptoms or prevent the progression of pathology in rheumatoid arthritis, lupus erythematosus, scleroderma, rheumatism, etc. Tablets Prednisolone is sometimes prescribed for oncology (during a course of chemotherapy), which helps prevent vomiting and nausea.
How do I take Prednisone in tablets?
The drug is taken orally during or immediately after eating, with water. Dosage tablets Prednisolone, is selected by a doctor individually. As a rule, the initial dose is 20 - 30 mg per day (2-3 times), then the amount of the drug gradually decreases.
Side effects of Prednisolone in tablets:
- insomnia;
- anxiety;
- swelling;
- increased blood pressure;
- amenorrhea ;
- alkalosis;
- increase in body weight;
- increased blood coagulability;
- increased acidity of gastric juice, etc.
Contraindications to taking tablets Prednisolone:
- arterial hypertension;
- kidney failure;
- peptic ulcer;
- diabetes;
- bacterial endocarditis;
- Itenko-Cushing's disease;
- osteoporosis;
- tuberculosis;
- syphilis;
- psychoses;
- pregnancy and lactation.