Ampicillin is a drug that belongs to the group of penicillin antibiotics. It is a semi-synthetic substance with a wide spectrum of activity relative to the causative agents of infectious diseases of a bacterial nature. Antibiotic Ampicillin is produced in various dosage forms, including in the form of tablets.
Indications for taking Ampicillin in tablets
The drug Ampicillin in the form of tablets is prescribed for mild diseases, provoked by a sensitive microflora, including mixed, namely:
- diseases of the ENT organs (angina, exacerbation of chronic tonsillitis, acute and chronic sinusitis, purulent pharyngitis, otitis, laryngitis, etc.);
- uncomplicated respiratory tract infections (bronchitis, tracheobronchitis );
- infection of the urinary and biliary systems (pyelonephritis, cystitis, cholecystitis, etc.);
- intestinal infections;
- chronic arthritis;
- infections of the skin and soft tissues ( furunculosis , suppurative ulcers, purulent wounds), etc.
In more serious cases (pneumonia, peritonitis, sepsis, etc.) Ampicillin can be prescribed in injectable forms. The purpose of this drug should be carried out only after planting the biomaterial on nutrient media, determining the causative agent of the disease and its sensitivity to antibiotic agents.
Pharmacological action and composition of tablets Ampicillin
The active substance of the drug is ampicillin trihydrate; additional ingredients: talcum, starch, calcium stearate. Tablets are well absorbed in the gastrointestinal tract, penetrating into the tissues and body fluids, do not break down in an acidic environment. Ampicillin does not accumulate in the body, it is excreted through the kidneys. The limiting concentration is observed after 90 - 120 minutes after administration. The drug helps suppress the synthesis of cell walls of the following microorganisms:
- streptococci;
- salmonella;
- shigella;
- Proteus;
- Listeria;
- E. coli ;
- Pfeiffer's wand, etc.
In relation to penicillinase-forming strains of microorganisms Ampicillin is not active.
Ampicillin dosage in tablets
As a rule, Ampicillin is taken four times a day for 250-500 mg. The medicine can be taken regardless of the meal. Duration of treatment varies from 5 to 21 days.
Contraindications to the use of Ampicillin in tablets:
- hypersensitivity to the drug;
- severe renal and hepatic insufficiency;
- allergic diseases (seasonal allergy, bronchial asthma);
- Infectious mononucleosis;
- lymphocytic leukemia;
- the period of breastfeeding.