Antibiotics of a wide spectrum of activity, including Unidox Solutab, are used in the treatment of almost all inflammatory diseases caused by bacteria . This drug is considered one of the most effective, but it is often tried to replace it due to a rather high cost. There are not many medications that can be bought instead of Unidox Solutab - the analogs usually have more side effects and are hepatotoxic.
What can replace Unidox Solutab?
The main active substance of the described tablets is doxycycline monohydrate. Its concentration in one capsule is 100 mg. In accordance with these indicators, a list has been drawn up, than to replace Unidox Solutab. The following preparations completely coincide composition and form of release:
- Vibramycin D;
- Doxa-M.
Apparently, absolutely analogous medicamental agents are few. This is due to the active component of the antibiotic in question. At the heart of Unidox Solutab is doxycycline in the form of monohydrate, which is formed as a result of a long and complex process of purifying this chemical compound. To produce it, modern and expensive equipment is required, which is not installed in all pharmaceutical factories.
Domestic analogues of Unidox tablets are also based on doxycycline, but of a different type, most often - giklata. Among them is worth paying attention to the following drugs:
- Bassado;
- Widokcin;
- Doxal;
- Doxilan;
- Dovitsin;
- Doksybeene;
- Tetracycline;
- Tigacil (only in powder for the preparation of a solution for intravenous infusion).
Also, one of the cheapest and most popular analogs of the drug is Doxycycline. It is also based on a giclate of the active ingredient at a concentration of 100 mg.
Doxycycline as an analogue of Unidox Solutab
There is an opinion that these medications are no different than cost, so many women often buy Doxycycline instead of the prescribed Unidox. This statement is erroneous for several reasons:
- Doxycycline is developed on the basis of giklata (hydrochloride), and Unidox Solutab is based on monohydrate. Despite the same concentration of active substance, it is absorbed by the body in different ways. So, the bioavailability of Doxycycline is only 50-55%. The same index of Unidox is 90-95%.
- Doxycycline is available in capsules, as well as injections, while Unidox Solutab is sold in the form of tablets and suspensions. These dosage forms are much more convenient, especially if necessary to dissolve the drug in water.
- The tablets of the drug in question dissolve and are absorbed in the intestine. Capsules of Doxycycline begin to act already in the stomach, which is fraught not only with complications for the digestive system in the form of spasms and pains,
but also leads to significant losses of the active component. - Doxycycline is very often accompanied by a side effect such as yellowing of tooth enamel. The instructions to Unidox Solutab also indicate the possibility of this effect, but such cases are extremely rare.
- Unidox is an original antibiotic that goes through several stages of thorough cleaning, therefore it is as safe as possible. Doxycycline is a synthetic analogue (a series of tetracyclines), concerning the effectiveness of which there are not so many clinical studies.
Thus, choosing the substitute antibiotic Unidox Solutab, it is important to pay attention not only to the composition of the drug, but also to the form of the active substance, the number of side effects.