Medication Cordarone with all of its indications and contraindications to use belongs to the group of antiarrhythmic drugs of the third class. That is, its action is based on blockade of potassium channels. The drug also has the properties of antiarrhythmics of the first and fourth class. And accordingly, it can simultaneously block sodium and calcium channels. Among other things, the drug has beta-adrenergic blocking, anti-anginal and coronary expansive effects.
Indications for use Kordaron tablets
The basis of the drug is amiodarone hydrochloride. The standard dosage of the active ingredient is 200 mg. In addition to it, the composition of the preparation includes such auxiliary components:
- anhydrous colloidal silicon dioxide;
- lactose monohydrate;
- magnesium stearate;
- corn starch;
- Povidone.
The drug Cordarone is indicated for use both for treatment and for prophylactic purposes. Assign it usually at:
- supraventricular paroxysmal tachycardias;
- ventricular arrhythmias;
- the Wolff-Parkinson-White syndrome;
- supraventricular and ventricular extrasystole ;
- atrial flutter;
- sinus tachycardia;
- recovery after myocardial infarction;
- acute phase of myocardial infarction;
- atrial fibrillation;
- violations of the functions of the ventricle;
- ischemic heart disease;
- attacks of angina pectoris .
How to use Kordaron tablets is determined by the attending physician. Different therapies can be used in therapy. So, for example, in an inpatient setting, the optimal initial dose is 600-800 mg of amiodarone hydrochloride, divided into several doses. The maximum permissible total daily dose is 10 g. And this treatment lasts from five to eight days.
The scheme of outpatient treatment is similar, but it should last a little longer - from ten days to two weeks. It is important to remember that the duration of the half-life of Kordaron is not too long, therefore it is recommended to use it every other day. You can also drink tablets with small - up to a couple of days - interruptions.
Begin treatment all experts recommend with a minimum dose and focus on the resulting therapeutic effect. If the latter is insufficient, then the dosage should be increased.
Contraindications to the use of Cordarone
Contraindications are almost any medicine. And Cordaron was no exception. It is not recommended to be treated with this antiarrhythmic drug when:
- hypersensitivity to the components of the composition;
- prolongation of the QT interval (both congenital and acquired);
- sinus bradycardia;
- sinoatrial blockade;
- pregnancy;
- breastfeeding;
- interstitial lung disease;
- hypokalemia;
- hypomagnesemia;
- thyroid dysfunctions (such as hyper- or hypothyroidism);
- atrioventicular blockade from the first to the third degree.
Children should not drink pills before eighteen. With extreme caution, Cordarone should be administered to patients with:
- arterial hypotension;
- decompensated or severe chronic heart failure;
- cardiogenic shock;
- bronchial asthma;
- cardiomyopathy;
- hepatic insufficiency.
Take medication under the supervision of a specialist, and elderly patients whose body is weakened by age-related changes and exposed to risks.
It is very undesirable to combine Cordarone with such medicines:
- Quinidine;
- Mefelohin;
- Quinine;
- Pimozide;
- Fluphenazine;
- Spiramycin;
- Misolastine;
- Sultopride;
- Terfenadine;
- Haloperidol;
- Bretilia;
- Sotalol;
- Spiramycin;
- Chlorpromazine;
- Ciammazine.