Eradication therapy

Previously , gastric ulcer was associated only with eating disorders and alcohol abuse, while the main factor triggering the disease is the Helicobacter pylori bacterium. Eradication therapy is a standard set of techniques designed to destroy this microorganism and ensure the normal functioning of the digestive system.

Scheme of eradication therapy Maastricht

A number of requirements are presented to the complex of medical measures:

To achieve these goals, the schemes are constantly being improved and adjusted in accordance with the decisions taken at the International Medical Conferences of Maastricht.

To date, there is a three-component technique and quadrotherapy, we will consider them in more detail.

Three-component eradication therapy Helikobakter Pilori

The triple technique is of two types: on the basis of bismuth preparations and on the basis of inhibitors of the proton pump of parietal cells.

In the first case, eradication therapy of peptic ulcer includes:

  1. Bismuth (120 mg) as a colloidal subcitrate or gallate or subalicylate.
  2. Tinidazole or Metronidazole. Each serving is 250 mg.
  3. Tetracycline is strictly 0.5 g.

All medications should be taken 4 times a day at the indicated dosage. The course of treatment is 1 week.

In the second case, the scheme looks like this:

  1. Omeprazole (20 mg) with Metronidazole (0.4 g 3 times a day) and another antibiotic - Clarithromycin (250 mg twice in 24 hours).
  2. Pantoprazole 0.04 g (40 mg) with Amoxicillin 1 g (1000 mg) 2 times a day, and Clarithromycin 0.5 g as well 2 times a day.

Proton pump inhibitors should be taken 2 times every 24 hours.

In the latter case, Pantoprazole can be replaced with Lanoprazole at a dosage of 30 mg twice a day.

The duration of the described therapy is 7 days.

It is important to note that eradication from 80% is considered successful, although this does not mean that the bacterium was completely destroyed. Due to the use of antibacterial drugs, the number of microorganisms is rapidly and significantly reduced and during the analysis they may not show up. At the end of the course the colony will be restored and the next treatment line will be required.

Four-component eradication therapy Helicobacter pylori

The scheme in question is assigned in case of unsuccessful results after the three-component treatment of both of the above-described species. It includes such medications:

  1. The preparation of bismuth is 120 mg 4 times a day.
  2. Combination of antibiotics - Tetracycline (4 times a day for 500 mg) with Metronidazole (250 mg 4 times in 24 hours) or Tinidazole (4 times a day for 250 mg).
  3. The proton pump inhibitor drug (one of three) is Omeprazole (0.02 grams) or Lansoprazole (0.03 grams) or Pantoprazole (0.04 grams) twice daily.

The total duration of therapy does not exceed 1 week.

When choosing antibacterial medicines, it is important to take into account the resistance of the Helicobacter pylori bacteria to such agents. It is known that microorganisms are least resistant to Amocycillin and Tetracycline. There are cases of development of rare resistance to Clarithromycin (about 14%). The highest immunity is observed to Metronidazole (about 55%).

Recent medical studies have shown that for successful eradication it is advisable to use new antibiotic drugs, for example, Rifabutin and Levofloxacin. To accelerate the healing of ulcers on the mucous surface of the stomach, it is recommended to additionally designate Sophalcon and Cetraxate.