Indomethacin is a drug that is available in various forms for local and systemic use, including in the form of tablets. Let's consider in more detail, at what pathologies the given tablets register, as they operate, what contraindications and by-effects they have.
Composition and pharmacological properties of tablets Indomethacin
The drug belongs to the group of non-steroidal anti-inflammatory and antirheumatic drugs. As the main component, it contains a substance with the same name, which is a derivative of indoleacetic acid. As additional ingredients, tablets, depending on the manufacturer, may contain: starch, silicon dioxide, lactose, talc, cellulose, sodium lauryl sulfate, etc. The tablets are coated with an enteric coating blocking the dissolution of the drug in the stomach.
Pharmacological properties of this drug are as follows:
- anti-inflammatory;
- anesthetizing;
- antipyretic.
These therapeutic effects are due to inhibition of the enzyme cyclooxygenase, which is contained in various tissues of the body and is responsible for the synthesis of prostaglandins. Prostaglandins cause pain in the focus of inflammation, an increase in temperature and an increase in the permeability of tissues; therefore, due to a decrease in their synthesis, these symptoms are suppressed.
The drug contributes to the weakening or elimination of the pain syndrome rheumatic and non-rheumatic nature, including affects the joint pain at rest and with activity. Also, it reduces the stiffness of the joints, expands the volume of movements, fights with swelling.
Indications for the use of tablets Indomethacin
These tablets are prescribed for symptomatic treatment of the following pathologies:
- inflammatory and degenerative diseases of the musculoskeletal system (rheumatoid arthritis, Bechterew's disease, Reiter's disease, gouty arthritis, psoriatic arthritis, etc.);
- lesions of periarticular tissues (bursitis, tendonitis, tendovaginitis, etc.);
- pain due to traumatic lesions and surgical manipulations;
- discopathy;
- radiculoneuritis;
- plexite;
- dysmenorrhea;
- adnexitis ;
- Infectious and inflammatory diseases of the ENT organs, etc.
Tablets are taken after meals or during it in individual dosages, depending on the type of disease and its severity.
Side effects of indomethacin
In the treatment of Indomethacin in tablets, the following adverse events may occur:
- nausea;
- abdominal pain;
- vomiting;
- stool disorders;
- headache;
- bleeding in the gastrointestinal tract;
- drowsiness;
- increased blood pressure;
- heart rhythm disturbances;
- itching;
- hives;
- anemia ;
- impaired vision;
- irritability, etc.
Contraindications Tablets Indomethacin
Medication Indomethacin in tablets is not allowed in such cases:
- hypersensitivity to the components of the agent;
- the presence in the anamnesis of a reaction to acetylsalicylic acid or other anti-inflammatory drugs with manifestations of an asthmatic attack, angioedema, hives, rhinitis;
- peptic ulcer;
- the presence of a history of gastrointestinal bleeding or perforation due to the use of a non-steroidal anti-inflammatory drug;
- severe heart failure;
- severe liver or kidney failure;
- pregnancy;
- the period of lactation.
During treatment with indomethacin, it is recommended to monitor the liver and kidneys, blood counts.