Normal human immunoglobulin is a drug-preventive drug that is considered to be a group of immunostimulating and immunomodulating agents. It is produced from the blood of healthy donors who have undergone special clinical examinations and laboratory tests and have no evidence of blood-borne infections (in particular, HIV infections, hepatitis C and B).
The main component of this drug is the immunologically active fraction of the blood protein, which is predominantly immunoglobulin G and contains immunoglobulin M and immunoglobulin A in small concentrations. The preparation is thoroughly purified, concentrated and viral inactivated during manufacturing. Normal human immunoglobulin does not contain preservatives and antibiotics, as a stabilizer contains glycine.
Form release and method of using normal human immunoglobulin
The medication can be produced in the form of a solution, packaged in ampoules, or as a lyophilizate for making a solution, packaged in bottles. In liquid form it is colorless or yellowish, transparent. The lyophilisate of a normal human immunoglobulin is a porous hygroscopic white mass. The human immunoglobulin is used for intramuscular (injections) and intravenous (dropper) administration.
Properties of normal human immunoglobulin
The drug has the properties of immunoglobulin G, which is available in healthy people. When it is introduced, the following effects are achieved:
- replenishment of missing IgG antibodies, which helps to reduce the risk of developing various infections;
- resumption of low IgG level to normal values;
- increased non-specific resistance of the human body;
- suppression and neutralization of a wide range of bacteria, viruses and other infectious agents.
Indications for the use of normal human immunoglobulin:
- congenital antibody deficiency syndrome;
- general variable immunodeficiency;
- iatrogenic immunodeficiency;
- chronic lymphocytic leukemia;
- myeloma;
- thrombocytopenic purpura of an immune origin with an increased risk of bleeding;
- Kawasaki's disease;
- bone marrow transplantation;
- severe infections of various origins;
- bacterial meningitis;
- Guillain-Barre syndrome;
- demyelinating inflammatory polyneuropathy in chronic form;
- hemolytic anemia;
- thrombocytopenia of an immune origin;
- autoimmune neutropenia;
- partial red cell aplasia of hematopoiesis;
- myasthenia gravis ;
- recurrent spontaneous miscarriage;
- hepatitis A;
- measles;
- polio;
- flu;
- whooping cough;
- meningococcal infections, etc.
Side effects and contraindications of normal human immunoglobulin
Side effects of taking normal human immunoglobulin:
- increased body temperature;
- headache;
- nausea;
- tachycardia;
- redness at the injection site;
- sweating, etc.
Contraindications to the introduction of normal human immunoglobulin:
- hypersensitivity to human immunoglobulin, blood products;
- the presence of antibodies to IgA.
With care, the medicine is used when:
- pregnancy, breast-feeding;
- diabetes mellitus;
- exacerbations of allergic processes;
- renal failure;
- nephrite;
- migraines;
- decompensated chronic heart failure;
- immune diseases of blood;
- collagenosis, etc.
Also, when using the drug, it is considered that its administration temporarily weakens the effect of living vaccines against pathologies such as rubella, measles, mumps and chicken pox.