In inflammations with an unknown pathogen or mixed infections (microbes, fungi), drugs with the widest possible spectrum of activity are necessary. 5-NOC is a complex antibacterial agent effective against most known microorganisms. It is effective against some mycoses.
5-NOC - composition
The main ingredient of the drug in question is nitroxoline. It is a derivative chemical compound from 8-hydroxyquinoline, it inhibits the synthesis of DNA from pathogenic cells and prevents their reproduction. The auxiliary components included in the 5-NOC-tablet formulation include:
- lactose monohydrate;
- calcium hydrogen phosphate;
- corn starch;
- Povidone K25;
- colloidal silicon dioxide;
- purified talc;
- magnesium stearate;
- crospovidone.
Pills are produced in a protective shell, which consists of the following substances:
- carmellose sodium;
- acacia gum;
- colloidal silicon dioxide;
- Povidone K25;
- titanium dioxide;
- corn starch;
- sucrose;
- purified talc;
- calcium carbonate;
- food colors - yellow "Sunset Sunset" (E110) and quinoline (E104).
5-NOC - indication
The drug is intended for the treatment of acute or slow recurrent infections of the urinary and reproductive systems. Tablets 5-NOC are effective against such groups of microorganisms:
- Gram-positive aerobic and anaerobic;
- gram-negative aerobic and anaerobic;
- mycoplasma ;
- ureaplasma ;
- Trichomonas;
- Mycobacterium tuberculosis;
- dermatophytes;
- mold fungi;
- candidate;
- pathogens provoking deep and severe mycoses.
5-NOC - indications for use:
- cystitis;
- pyelonephritis ;
- epididymitis;
- urethritis;
- infected tumor (adenoma, carcinoma) of the prostate;
- prostatitis;
- inflammatory processes in the bladder or outgoing tract.
The described preparation is used to prevent infection in such situations:
- postoperative period;
- diagnostic manipulation;
- cystoscopy ;
- catheterization.
5-NOC - side effects
Strong antibacterial medication can provoke negative reactions of the body from any system. This means rarely leads to side effects. In exceptional cases, the 5-NOC preparation causes:
- tachycardia;
- vomiting;
- anorexia;
- nausea;
- impaired liver function;
- dizziness;
- optic neuritis (with prolonged admission);
- paresthesia;
- lack of coordination;
- headache;
- polyneuropathy;
- thrombocytopenia;
- increased concentration of uric acid;
- urticaria;
- itching of the skin;
- ataxia;
- staining the urine in a rich yellow color.
5-NOC contraindications
This tool is not recommended for individual intolerance to any of the ingredients listed above, including auxiliary chemical compounds and shell components. The 5-NOC drug is contraindicated under such conditions:
- pregnancy;
- cataract;
- breast-feeding;
- severe disruption of the liver or kidney with a creatinine clearance of less than 20 ml / min (prescribed rarely, with caution);
- age up to 3 years.
How to take 5-NOC tablets?
The standard daily portion of the medication depends on the age and the presence of some chronic diseases. Adults a day require 400 mg of the drug 5-NOC - the application involves taking this dose, divided into 4 times, 100 mg (2 tablets) before meals. With a strong bacterial lesion, the portion is doubled (800 mg). Children over 5 years of age are prescribed 200-400 mg of medication every 24 hours, and children 3-5 years of age - 200 mg. The general course of therapy does not exceed 2-4 weeks, if necessary, repeat it.
With renal and hepatic insufficiency, 5-NOC is used with maximum caution - indications for use do not include these diseases, but in severe infections, an antibiotic can be prescribed. In these cases, take 1 tablet 4 times a day. It is necessary to regularly monitor the reaction of the kidney and liver to treatment and monitor the level of creatinine clearance.
5-NOC - an application for cystitis
The dosage of the antimicrobial agent corresponds to a standard dose of 400 mg nitroxoline every 24 hours. 5-NOC with cystitis is recommended course of 10-21 days. The exact duration of therapy is calculated by a urologist based on laboratory tests, the severity of the inflammatory process, and the presence of side effects from treatment. Sometimes it must be extended to 1 month, especially if the infection is combined or secondary.
5-NOC with pyelonephritis
The described illness in acute form requires a short course of standard antibiotic therapy, 400 mg daily for 2-2.5 weeks. In chronic course of recurrent pyelonephritis, the urologist decides how to take 5-NOC. There are schemes of long intermittent treatment (2-3 months for 14 days) and variants with a longer use of the drug in a lower dosage (100-200 mg).
Sometimes it takes the longest reception of 5-NOC - indications for use include severe forms of pyelonephritis:
- xanthogranulomatous;
- purulent;
- calculous.
5-NOC in pregnancy
Throughout the gestation period, the woman's urinary system is very vulnerable and is susceptible to inflammatory processes. Because of this, expectant mothers often are interested in 5-NOC - can I drink it during pregnancy and in what dosages. This antibiotic is contraindicated in this situation, because it can adversely affect the development or formation of the fetus.
5-NOC analogues
When the presented antimicrobial drug can not be used or it provokes serious side effects, it will have to be canceled. The only way to replace 5-NOC tablets is by using identical synonyms or generics. There are two direct analogs to the described drug:
- Nitroxoline (Germany, Russia);
- Uroksolin (Ukraine).
The first drug is produced with a different concentration of the active ingredient, which is convenient for the therapy with higher dosages. The second remedy is only in tablets with an active chemical content of 50 mg. If intolerance to nitroxoline or its derivatives is detected, it is necessary to use a generic. This drug has almost identical characteristics with 5-NOC - the main indications for use, antibacterial and antifungal activity, but a different composition. Effective medications are presented in the form of bacteriophages:
- dysentery polyvalent;
- intesties;
- if;
- staphylococcal;
- Protein;
- Klebsiella pneumonia;
- Pseudomonas (pseudomonas);
- kolik-proteyny;
- salmonella.
Other generics with identical indications:
- Fosmicin;
- Ureacid;
- Fosmural;
- Bernie;
- Fosmicin;
- Monural;
- Phosphoral;
- Urophosfabol;
- Cystoral;
- Forterase;
- Urofoscin;
- Phosphocin;
- Espa-Focine.